The overuse of antimicrobials leads to the development of bacterial resistance and makes patients susceptible to Clostridium difficile and other serious infections, yet many hospitalized patients continue to receive antimicrobials that are inappropriate or unnecessary.1 In a new study in Morbidity and Mortality Weekly Report, Fridkin and colleagues,2 using administrative data from 323 hospitals in the United States, found that 55.7% of inpatients received antimicrobials. Furthermore, using data from the Emerging Infections Program at the Centers for Disease Control and Prevention (CDC) and applying objective criteria for “potential improvement” in antimicrobial use at 36 hospitals, they report opportunities for improvement in the use of these medications in 37% of patients receiving vancomycin or treatment for urinary tract infection (UTI). It is disheartening that despite years of work, little progress has been made.3 In fact, Alexander Fleming warned against the overuse of penicillin in 1945.4 Nearly 70 years later, however, his call is being repeated. Why?
Thank you for submitting a comment on this article. It will be reviewed by JAMA Internal Medicine editors. You will be notified when your comment has been published. Comments should not exceed 500 words of text and 10 references.
Do not submit personal medical questions or information that could identify a specific patient, questions about a particular case, or general inquiries to an author. Only content that has not been published, posted, or submitted elsewhere should be submitted. By submitting this Comment, you and any coauthors transfer copyright to the journal if your Comment is posted.
* = Required Field
Disclosure of Any Conflicts of Interest*
Indicate all relevant conflicts of interest of each author below, including all relevant financial interests, activities, and relationships within the past 3 years including, but not limited to, employment, affiliation, grants or funding, consultancies, honoraria or payment, speakers’ bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued. If all authors have none, check "No potential conflicts or relevant financial interests" in the box below. Please also indicate any funding received in support of this work. The information will be posted with your response.
Some tools below are only available to our subscribers or users with an online account.
Download citation file:
Web of Science® Times Cited: 1
Customize your page view by dragging & repositioning the boxes below.
More Listings atJAMACareerCenter.com >
Enter your username and email address. We'll send you a link to reset your password.
Enter your username and email address. We'll send instructions on how to reset your password to the email address we have on record.
Athens and Shibboleth are access management services that provide single sign-on to protected resources. They replace the multiple user names and passwords necessary to access subscription-based content with a single user name and password that can be entered once per session. It operates independently of a user's location or IP address. If your institution uses Athens or Shibboleth authentication, please contact your site administrator to receive your user name and password.