A total of 5 415 084 veterans had VA outpatient visits in 2011, and 2 889 385 (53.4%) had VA HCV screening. The HCV screening rate was 40.6% for those born before 1945, 63.5% for those born during the 1945-1965 period, and 57.0% for those born after 1965 (eTable in the Supplement). The confirmatory RNA testing rate was 94.7% overall (eTable in the Supplement). Anti-HCV prevalence in over 2.8 million veterans was 8.4% and varied by birth cohort (Table). Prevalence of HCV infection was 6.2% and varied by birth cohort: 1.7% for those born before 1945, 10.3% for those born during the 1945-1965 period, and 1.1% for those born after 1965 (Table). By birth year, HCV infection prevalence peaked at 18.4% in those born in 1954 (Figure). Prevalence of HCV infection was higher in men (6.5%) than in women (2.8%) and was highest in blacks (12.3%), followed by Hispanics (6.7%) and American Indians/Alaska Natives (6.6%). Within each sex and race/ethnicity group, HCV infection prevalence was highest in those born during the 1945-1965 period, much lower in those born before 1945, and generally lowest in those born after 1965. Among men born from 1945 through 1965, prevalence ranged from 18.2% in blacks to 3.5% in Asians (eFigure 1A in the Supplement); although prevalence in black women was highest (5.7%), prevalence was appreciably lower with less variation across race/ethnicity subgroups in women (eFigure 1B in the Supplement).