Research Letters |

Time Trends of Mortality From Colorectal Cancer in the United States: A Birth-Cohort Analysis

Brent Y. Lee, MD; Amnon Sonnenberg, MD, MSc
JAMA Intern Med. 2013;173(12):1148-1150. doi:10.1001/jamainternmed.2013.656.
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The occurrence of colorectal cancer in the United States is decreasing.1 We sought to determine whether the decrease began prior to increased colorectal cancer screening.

Correspondence: Dr Sonnenberg, Division of Gastroenterology, Portland VA Medical Center, P3-GI, 3710 SW US Veterans Hospital Rd, Portland, OR 97239 (sonnenbe@ohsu.edu).

Published Online: April 29, 2013. doi:10.1001/jamainternmed.2013.656

Author Contributions:Study concept and design: Sonnenberg. Acquisition of data: Lee. Analysis and interpretation of data: Lee. Drafting of the manuscript: Lee. Critical revision of the manuscript for important intellectual content: Lee and Sonnenberg. Statistical analysis: Sonnenberg.

Conflict of Interest Disclosures: Dr Sonnenberg was supported by a grant from Takeda Pharmaceuticals. No funding was obtained for the present study.

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Figure. Age-specific death rates of rectum cancer and colon cancer plotted against the period of birth as cohort-age contours. W Indicates white subjects; NW, nonwhite subjects. A, B, D, and E, Age-specific death rates of rectum and colon cancer plotted as cohort-age contours; the curve of each 10-year age group is labeled by the number representing its central year, for instance, 80 indicating the age group 75 to 84 years. C and F, Standardized cohort-mortality ratios of rectum and colon cancer plotted against the year of birth and stratified by W and NW subjects.




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