Accepted for Publication: January 2, 2012.
Author Contributions: Dr Albrich had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: Albrich, Dusemund, Schuetz, and Mueller. Acquisition of data: Albrich, Dusemund, Bucher, Meyer, Thomann, Kühn, Bassetti, Sprenger, Bachli, Sigrist, Schwietert, Amin, Hausfater, Carre, Regez, Bossart, and Schild. Analysis and interpretation of data: Albrich, Dusemund, Bassetti, Schuetz, and Mueller. Drafting of the manuscript: Albrich and Dusemund. Critical revision of the manuscript for important intellectual content: Albrich, Dusemund, Bucher, Meyer, Thomann, Kühn, Bassetti, Sprenger, Bachli, Sigrist, Schwietert, Amin, Hausfater, Gaillat, Schuetz, Regez, Bossart, Schild, and Mueller. Statistical analysis: Albrich, Dusemund, and Schuetz. Obtained funding: Mueller. Administrative, technical, and material support: Albrich, Dusemund, Kühn, Sprenger, Bachli, Sigrist, Schwietert, Amin, Hausfater, Regez, Bossart, Schild, and Mueller. Study supervision: Albrich, Dusemund, Hausfater, Schuetz, and Mueller.
Financial Disclosure: Drs Albrich, Schuetz, and Mueller have received support from BRAHMS AG to attend meetings and fulfill speaking engagements. Dr Amin has received speaking honoraria from bioMérieux. Drs Albrich and Mueller have received support from bioMérieux to attend meetings. Dr Mueller has served as a consultant to and received research support from BRAHMS AG and bioMérieux.
ProREAL Study Team Members: Kantonsspital Aarau, Aarau, Switzerland: Werner C. Albrich, MD, MSCR; Frank Dusemund, MD; Birgit Bucher; Stefan Meyer; Katharine Regez, RN; Rita Bossart, RN, PhD; Ursula Schild, RN; Beat Mueller, MD; Marcus Batschwaroff, MD; Birsen Arici; Alexander Litke; Ulrich Bürgi, MD; Andreas Huber, MD; Sarosh Irani, MD; and Renate Hunziker. Bürgerspital Solothurn, Solothurn, Switzerland: Robert Thomann, MD. Kantonsspital Olten, Olten, Switzerland: Felix Kühn, MD, and Stefano Bassetti, MD. Spital Uster, Uster, Switzerland: Martin Sprenger, MD, and Ester Bachli, MD. Kreisspital für das Freiamt Muri, Muri, Switzerland: Alexander Spillmann, MD. Spital Menziken, Menziken, Switzerland: Slavka Kraljevic, MD. Kantonsspital Liestal, Liestal, Switzerland: Martin Schwietert, MD, and Werner Zimmerli, MD. Klinik Barmelweid, Barmelweid, Switzerland: Thomas Sigrist, MD, and Martin Frey, MD. Institut für Arbeitsmedizin, Baden, Switzerland: Daniel Rodriguez, MD. Morton Plant Hospital, Clearwater, Florida: Devendra Amin, MD. Harvard School of Public Health, Boston, Massachusetts: Philipp Schuetz, MD, MPH. Hôpital Pitié-Salpétriêre, Paris, France: Piere Hausfater, MD, PhD; Viviane Montout, MD; and Beatrice Madonna-Py, MD. Baume-les-Dames, France: Eric Carre, MD. Centre Hospitalier de la Région d’Annecy, Annecy, France: Jacques Gaillat, MD, and Gaëlle Pillaut, MD.
Funding/Support: bioMérieux provided PCT kits and testing devices and provided a small financial compensation per enrolled patient.
Role of the Sponsor: bioMérieux had no role in the design and conduct of the study; in the collection, analysis, and interpretation of the data; or in the preparation, review, or approval of the manuscript.
Additional Contributions: Michael Fine, MD, MSc, provided helpful comments and advice. We are grateful to all the patients, physicians, and nursing staff from the centers who participated in this survey.