This randomized clinical trial compares the effects of moderate and vigorous exercise on intrahepatic triglyceride content and metabolic risk factors among patients with nonalcoholic fatty liver disease.
This randomized clinical trial compared 2 self-regulation interventions vs control in reducing weight gain in young adults over a mean follow-up of 3 years.
This article summarizes an evidence report for the California Technology Assessment Forum about the comparative effectiveness and value of surgical, device, and new drug vs lifestyle, diet, and existing drug treatment of obesity.
This observational cohort study at 10 US hospitals examines change in urinary incontinence before and after bariatric surgery and identifies factors associated with improvement and remission among women and men in the first 3 years after bariatric surgery.
Bennett et al compared changes in weight and cardiometabolic risk during a 12-month period among black women randomized to a primary care–based behavioral weight gain prevention intervention, relative to usual care. See invited critique by Benjamin et al.
Limitations in mobility are common among older adults with cardiovascular and cardiometabolic disorders and have profound effects on health and well-being. With the growing population of older adults in the United States, effective and scalable public health approaches are needed to address this problem. Our goal was to determine the effects of a physical activity and weight loss intervention on 18-month change in mobility among overweight or obese older adults in poor cardiovascular health.
The study design was a translational, randomized controlled trial of physical activity (PA) and weight loss (WL) on mobility in overweight or obese older adults with cardiovascular disease (CVD) or at risk for CVD. The study was conducted within the community infrastructure of Cooperative Extension Centers. Participants were randomized to 1 of 3 interventions: PA, WL + PA, or a successful aging (SA) education control arm. The primary outcome was time to complete a 400-m walk in seconds (400MWT).
A significant treatment effect (P = .002) and follow-up testing revealed that the WL + PA group improved their 400MWT (adjusted mean [SE], 323.3 [3.7] seconds) compared with both PA (336.3 [3.9] seconds; P = .02) and SA (341.3 [3.9] seconds; P < .001). Participants with poorer mobility at baseline benefited the most (P < .001).
Existing community infrastructures can be effective in delivering lifestyle interventions to enhance mobility in older adults in poor cardiovascular health with deficits in mobility; attention should be given to intervening on both weight and sedentary behavior since weight loss is critical to long-term improvement in mobility.
clinicaltrials.gov Identifier: NCT00119795