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  • Alternative Strategies to Inpatient Hospitalization for Acute Medical Conditions: A Systematic Review

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    JAMA Intern Med. 2016; doi: 10.1001/jamainternmed.2016.5974

    This systematic review examines the effectiveness, safety, and cost of treating acute medical conditions in settings outside of a hospital inpatient unit.

  • Efficacy of Folic Acid Therapy on the Progression of Chronic Kidney Disease: The Renal Substudy of the China Stroke Primary Prevention Trial

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    JAMA Intern Med. 2016; 176(10):1443-1450. doi: 10.1001/jamainternmed.2016.4687

    This secondary analysis of China Stroke Primary Prevention Trial data compares the effects of folic acid and enalapril vs enalapril alone on progression of CKD.

  • Duration of Antibiotic Treatment in Community-Acquired Pneumonia: A Multicenter Randomized Clinical Trial

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    JAMA Intern Med. 2016; 176(9):1257-1265. doi: 10.1001/jamainternmed.2016.3633

    This noninferiority trial compares the effects of IDSA/ATS guideline–recommended vs conventional antibiotic treatment duration on symptom and clinical resolution in hospitalized patients with community-acquired pneumonia.

  • Cancer Center Advertising—Where Hope Meets Hype

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    JAMA Intern Med. 2016; 176(8):1068-1070. doi: 10.1001/jamainternmed.2016.3278
  • Characteristics and Outcomes of Patients Presenting With Hypertensive Urgency in the Office Setting

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    JAMA Intern Med. 2016; 176(7):981-988. doi: 10.1001/jamainternmed.2016.1509

    This cohort study investigates whether referral to the hospital is associated with better outcomes in a population of patients presenting with hypertensive urgency in the office setting.

  • Characteristics of Patients Undergoing Cardiac Catheterization Before Noncardiac Surgery: A Report From the National Cardiovascular Data Registry CathPCI Registry

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    JAMA Intern Med. 2016; 176(5):611-618. doi: 10.1001/jamainternmed.2016.0259

    This study describes the characteristics, angiographic findings, and treatment patterns of patients with stable angina symptoms undergoing cardiac catheterization and/or percutaneous coronary intervention before noncardiac surgery in a large national registry.

  • New Approaches to Reduce Readmissions in Patients With Heart Failure

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    JAMA Intern Med. 2016; 176(3):318-320. doi: 10.1001/jamainternmed.2015.7993
  • Monthly High-Dose Vitamin D Treatment for the Prevention of Functional Decline: A Randomized Clinical Trial

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    JAMA Intern Med. 2016; 176(2):175-183. doi: 10.1001/jamainternmed.2015.7148

    This randomized clinical trial compared the effects of 3 doses of monthly vitamin D on lower extremity function in community dwelling adults age 70 and older who had previously fallen.

  • Sacubitril-Valsartan for the Treatment of Heart Failure: Effectiveness and Value

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    JAMA Intern Med. 2016; 176(2):249-250. doi: 10.1001/jamainternmed.2015.7661

    This evidence review examines whether the sacubitril-valsartan benefits seen in a trial persist over many years, its cost-effectiveness, and its budgetary impact on the health care system.

  • Cost-effectiveness of Early Treatment of Hepatitis C Virus Genotype 1 by Stage of Liver Fibrosis in a US Treatment-Naive Population

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    JAMA Intern Med. 2016; 176(1):65-73. doi: 10.1001/jamainternmed.2015.6011

    This decision-analytic model of treatment for hepatitis C virus genotype 1 assesses the cost-effectiveness of treating all patients with hepatitis C virus infection at all stages of fibrosis vs those with advanced fibrosis only in a US treatment-naive population sample.

  • Prescription Strategies in Acute Uncomplicated Respiratory Infections: A Randomized Clinical Trial

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    JAMA Intern Med. 2016; 176(1):21-29. doi: 10.1001/jamainternmed.2015.7088

    This trial of patients with uncomplicated respiratory infections randomizes participants to 1 of 4 antibiotic prescription strategies to determine whether delayed antibiotic strategies are associated with greater symptom burden and duration, as well as reduced antibiotic use.

  • Treating Influenza With Neuraminidase Inhibitors: What Is the Evidence?

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    JAMA Intern Med. 2015; 175(12):1899-1900. doi: 10.1001/jamainternmed.2015.5747

    This short review of the literature on neuraminidase inhibitor effectiveness on influenza virus concludes that, while randomized clinical trials are lacking, observation data suggest benefit, especially in high-risk patients.

  • Cancer Drugs Approved on the Basis of a Surrogate End Point and Subsequent Overall Survival: An Analysis of 5 Years of US Food and Drug Administration Approvals

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    JAMA Intern Med. 2015; 175(12):1992-1994. doi: 10.1001/jamainternmed.2015.5868

    This review of approvals of cancer drugs based on a surrogate end point by the US Food and Drug Administration assesses the postmarketing findings for overall survival.

  • Shared Decision Making for Antidepressants in Primary Care: A Cluster Randomized Trial

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    JAMA Intern Med. 2015; 175(11):1761-1770. doi: 10.1001/jamainternmed.2015.5214

    This cluster randomized trial studied the effectiveness of the Depression Medication Choice decision aid to help patients with moderate to severe depression and clinicians choose antidepressants together and found it improved the decision-making process and quality of care.

  • The Role of Decision Aids in Depression Care

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    JAMA Intern Med. 2015; 175(11):1770-1772. doi: 10.1001/jamainternmed.2015.5243
  • Long-term Clinical Outcomes of Splanchnic Vein Thrombosis: Results of an International Registry

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    JAMA Intern Med. 2015; 175(9):1474-1480. doi: 10.1001/jamainternmed.2015.3184

    This cohort study evaluates the long-term outcomes of splanchnic vein thrombosis in patients with differing risk factors and treatments.

  • Cognitive Behavioral Therapy for Insomnia Comorbid With Psychiatric and Medical Conditions: A Meta-analysis

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    JAMA Intern Med. 2015; 175(9):1461-1472. doi: 10.1001/jamainternmed.2015.3006

    This meta-analysis evaluates the use of cognitive behavioral therapy for treatment of insomnia in patients with comorbid medical or psychiatric conditions.

  • Treating Insomnia Disorder in the Context of Medical and Psychiatric Comorbidities

    Abstract Full Text
    JAMA Intern Med. 2015; 175(9):1472-1473. doi: 10.1001/jamainternmed.2015.3015
  • Addressing Overuse of Medical Services One Decision at a Time

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    JAMA Intern Med. 2015; 175(7):1092-1093. doi: 10.1001/jamainternmed.2015.1693

    This Editorial discusses overuse of medical services and proposes ways to assess and reduce patterns of overuse.

  • Variability Among US Intensive Care Units in Managing the Care of Patients Admitted With Preexisting Limits on Life-Sustaining Therapies

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    JAMA Intern Med. 2015; 175(6):1019-1026. doi: 10.1001/jamainternmed.2015.0372

    This cohort study reports that intensive care units vary dramatically in how they manage care for patients admitted with treatment limitations.