This systematic review examines the effectiveness, safety, and cost of treating acute medical conditions in settings outside of a hospital inpatient unit.
This secondary analysis of China Stroke Primary Prevention Trial data compares the effects of folic acid and enalapril vs enalapril alone on progression of CKD.
This noninferiority trial compares the effects of IDSA/ATS guideline–recommended vs conventional antibiotic treatment duration on symptom and clinical resolution in hospitalized patients with community-acquired pneumonia.
This cohort study investigates whether referral to the hospital is associated with better outcomes in a population of patients presenting with hypertensive urgency in the office setting.
This study describes the characteristics, angiographic findings, and treatment patterns of patients with stable angina symptoms undergoing cardiac catheterization and/or percutaneous coronary intervention before noncardiac surgery in a large national registry.
This randomized clinical trial compared the effects of 3 doses of monthly vitamin D on lower extremity function in community dwelling adults age 70 and older who had previously fallen.
This evidence review examines whether the sacubitril-valsartan benefits seen in a trial persist over many years, its cost-effectiveness, and its budgetary impact on the health care system.
This decision-analytic model of treatment for hepatitis C virus genotype 1 assesses the cost-effectiveness of treating all patients with hepatitis C virus infection at all stages of fibrosis vs those with advanced fibrosis only in a US treatment-naive population sample.
This trial of patients with uncomplicated respiratory infections randomizes participants to 1 of 4 antibiotic prescription strategies to determine whether delayed antibiotic strategies are associated with greater symptom burden and duration, as well as reduced antibiotic use.
This short review of the literature on neuraminidase inhibitor effectiveness on influenza virus concludes that, while randomized clinical trials are lacking, observation data suggest benefit, especially in high-risk patients.
This review of approvals of cancer drugs based on a surrogate end point by the US Food and Drug Administration assesses the postmarketing findings for overall survival.
This cluster randomized trial studied the effectiveness of the Depression Medication Choice decision aid to help patients with moderate to severe depression and clinicians choose antidepressants together and found it improved the decision-making process and quality of care.
This cohort study evaluates the long-term outcomes of splanchnic vein thrombosis in patients with differing risk factors and treatments.
This meta-analysis evaluates the use of cognitive behavioral therapy for treatment of insomnia in patients with comorbid medical or psychiatric conditions.
This Editorial discusses overuse of medical services and proposes ways to assess and reduce patterns of overuse.
This cohort study reports that intensive care units vary dramatically in how they manage care for patients admitted with treatment limitations.