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  • A Grateful but Not Passive Patient

    Abstract Full Text
    JAMA Intern Med. 2016; 176(9):1248-1249. doi: 10.1001/jamainternmed.2016.3569
  • Aspirin for Primary Prevention of Atherosclerotic Cardiovascular Disease: Advances in Diagnosis and Treatment

    Abstract Full Text
    JAMA Intern Med. 2016; 176(8):1195-1204. doi: 10.1001/jamainternmed.2016.2648

    This review examines which patients derive benefit from being prescribed aspirin for the primary prevention of atherosclerotic cardiovascular disease.

  • The Promise of Leisure-Time Physical Activity to Reduce Risk of Cancer Development

    Abstract Full Text
    JAMA Intern Med. 2016; 176(6):826-827. doi: 10.1001/jamainternmed.2016.1521
  • Dietary Patterns and Fractures in Postmenopausal Women: Results From the Women’s Health Initiative

    Abstract Full Text
    JAMA Intern Med. 2016; 176(5):645-652. doi: 10.1001/jamainternmed.2016.0482

    This post hoc analysis of the Women’s Health Initiative study examines the effects of adherence to differing dietary recommendations and risk for hip fracture in postmenopausal women.

  • Variability in DXA Reporting and Other Challenges in Osteoporosis Evaluation

    Abstract Full Text
    JAMA Intern Med. 2016; 176(3):393-395. doi: 10.1001/jamainternmed.2015.7550
  • Exercise and the Prevention of Low Back Pain: Ready for Implementation

    Abstract Full Text
    JAMA Intern Med. 2016; 176(2):208-209. doi: 10.1001/jamainternmed.2015.7636
  • Contamination of Health Care Personnel During Removal of Personal Protective Equipment

    Abstract Full Text
    JAMA Intern Med. 2015; 175(12):1904-1910. doi: 10.1001/jamainternmed.2015.4535

    This point-prevalence study of health care personnel reports on educational interventions to reduce the risk of contamination during removal of personal protective equipment.

  • Mediterranean Diet and Invasive Breast Cancer Risk Among Women at High Cardiovascular Risk in the PREDIMED Trial: A Randomized Clinical Trial

    Abstract Full Text
    JAMA Intern Med. 2015; 175(11):1752-1760. doi: 10.1001/jamainternmed.2015.4838

    Results of this secondary analysis of the PREDIMED trial suggest a beneficial effect of a Mediterranean diet supplemented with extra-virgin olive oil in the primary prevention of breast cancer.

  • Participation in Cardiac Rehabilitation Programs Among Older Patients After Acute Myocardial Infarction

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    JAMA Intern Med. 2015; 175(10):1700-1702. doi: 10.1001/jamainternmed.2015.3819

    This analysis of clinical data linked to Medicare claims finds the cardiac rehabilitation rate for older patients after acute myocardial infarction is low in the United States and suggests efforts be made for increasing referrals, and addressing attendance barriers, to rehabilitation sessions.

  • Leisure Time Physical Activity and Mortality: A Detailed Pooled Analysis of the Dose-Response Relationship

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    JAMA Intern Med. 2015; 175(6):959-967. doi: 10.1001/jamainternmed.2015.0533

    This pooled analysis reports a benefit threshold at approximately 3 to 5 times the recommended leisure time physical activity minimum and no excess risk at 10 or more times the minimum. See the Invited Commentary by Manini.

  • A Guide to Reading Health Care News Stories

    Abstract Full Text
    JAMA Intern Med. 2014; 174(7):1183-1186. doi: 10.1001/jamainternmed.2014.1359

    Schwitzer provides a guide to reading health care news stories to help physicians and the public better understand the strengths and weaknesses of news media coverage of medical and health topics

  • The Risk of Long-term Morbidity and Mortality in Patients With Chronic Hepatitis C: Results From an Analysis of Data From a Department of Veterans Affairs Clinical Registry

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    JAMA Intern Med. 2014; 174(2):204-212. doi: 10.1001/jamainternmed.2013.12505

    McCombs and colleagues describe the natural history of hepatitis C virus in real-world clinical practice.

  • Risk and Risk Reduction of Major Coronary Events Associated With Contemporary Breast Radiotherapy

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    JAMA Intern Med. 2014; 174(1):158-160. doi: 10.1001/jamainternmed.2013.11790
  • Continuity of Care and the Risk of Preventable Hospitalization in Older Adults

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    JAMA Intern Med. 2013; 173(20):1879-1885. doi: 10.1001/jamainternmed.2013.10059

    Nyweide and coauthors determined whether Medicare patients with ambulatory visit patterns indicating higher continuity of care have a lower risk of preventable hospitalization. See the Invited Commentary by Gupta and Bodenheimer.

  • Intervention to Influence Behaviors Linked to Risk of Chronic Diseases: A Multisite Randomized Controlled Trial With African-American HIV-Serodiscordant Heterosexual Couples

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    Arch Intern Med. 2011; 171(8):728-736. doi: 10.1001/archinternmed.2011.136
  • National Institute of Mental Health Multisite Eban HIV/STD Prevention Intervention for African American HIV Serodiscordant Couples: A Cluster Randomized Trial

    Abstract Full Text
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    Arch Intern Med. 2010; 170(17):1594-1601. doi: 10.1001/archinternmed.2010.261

    Human immunodeficiency virus (HIV) has disproportionately affected African Americans. Couple-level interventions may be a promising intervention strategy.


    To determine if a behavioral intervention can reduce HIV/sexually transmitted disease (STD) risk behaviors among African American HIV serodiscordant couples, a cluster randomized controlled trial (Eban) was conducted in Atlanta, Georgia; Los Angeles, California; New York, New York; and Philadelphia, Pennsylvania; with African American HIV serodiscordant heterosexual couples who were eligible if both partners were at least 18 years old and reported unprotected intercourse in the previous 90 days and awareness of each other's serostatus. One thousand seventy participants were enrolled (mean age, 43 years; 40% of male participants were HIV positive). Couples were randomized to 1 of 2 interventions: couple-focused Eban HIV/STD risk-reduction intervention or attention-matched individual-focused health promotion comparison. The primary outcomes were the proportion of condom-protected intercourse acts and cumulative incidence of STDs (chlamydia, gonorrhea, or trichomonas). Data were collected preintervention and postintervention, and at 6- and 12-month follow-ups.


    Data were analyzed for 535 randomized couples: 260 in the intervention group and 275 in the comparison group; 81.9% were retained at the 12-month follow-up. Generalized estimating equation analyses revealed that the proportion of condom-protected intercourse acts was larger among couples in the intervention group (0.77) than in the comparison group (0.47; risk ratio, 1.24; 95% confidence interval [CI], 1.09 to 1.41; P = .006) when adjusted for the baseline criterion measure. The adjusted percentage of couples using condoms consistently was higher in the intervention group (63%) than in the comparison group (48%; risk ratio, 1.45; 95% CI, 1.24 to 1.70; P < .001). The adjusted mean number of (log)unprotected intercourse acts was lower in the intervention group than in the comparison group (mean difference, −1.52; 95% CI, −2.07 to −0.98; P < .001). The cumulative STD incidence over the 12-month follow-up did not differ between couples in the intervention and comparison groups. The overall HIV seroconversion at the 12-month follow-up was 5 (2 in the intervention group, 3 in the comparison group) of 535 individuals, which translates to 935 per 100 000 population.


    To our knowledge, this is the first randomized controlled intervention trial to report significant reductions in HIV/STD risk behaviors among African American HIV serodiscordant couples.

    Trial Registration Identifier: NCT00644163

  • By Jove! What Is a Clinician to Make of JUPITER?

    Abstract Full Text
    Arch Intern Med. 2010; 170(12):1073-1077. doi: 10.1001/archinternmed.2010.189
  • Sustained Vertebral Fracture Risk Reduction After Withdrawal of Teriparatide in Postmenopausal Women With Osteoporosis

    Abstract Full Text
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    Arch Intern Med. 2004; 164(18):2024-2030. doi: 10.1001/archinte.164.18.2024
  • HIV Sexual Risk Reduction Intervention With Heterosexual Men

    Abstract Full Text
    Arch Intern Med. 2003; 163(6):738-739. doi: 10.1001/archinte.163.6.738-a
  • JAMA Internal Medicine

    Figure: Evaluating the Incremental Benefits of Raising High-Density Lipoprotein Cholesterol Levels During Lipid Therapy After Adjustment for the Reductions in Other Blood Lipid Levels

    Hazard ratios (HRs) associated with changes in high-density lipoprotein cholesterol (HDL-C) level. The model was adjusted for the pretreatment levels of low-density lipoprotein cholesterol (LDL-C) and HDL-C, the change in LDL-C level, and the interaction between the change in HDL-C level and pretreatment LDL-C levels. The interaction results in greater risk reduction associated with a 5-mg/dL increase in HDL-C level among individuals with lower LDL-C levels. To convert cholesterol to millimoles per liter, multiply by 0.0259.