This randomized clinical trial evaluates the use of high-dose sodium selenite, with or without use of a procalcitonin algorithm to guide therapy, and its association with mortality in patients with severe sepsis.
This case series explores the safety considerations of clarithromycin by investigating the association between Helicobacter pylori therapy containing clarithromycin and acute neuropsychiatric events.
Clark et al compare the risk of excessive anticoagulation among patients with stable warfarin therapy purchasing an antibiotic with the risk in patients purchasing a warfarin refill and patients with upper respiratory tract infection but not receiving an antibiotic. Katz provides an editorial.
This case illustrates how unnecessary antibiotic use might cause life-threatening adverse events in the context of certain types of heart disease.
This meta-analysis evaluates the use of cognitive behavioral therapy for treatment of insomnia in patients with comorbid medical or psychiatric conditions.
Marklund and coauthors test whether an adjustable, custom-made oral appliance improves daytime sleepiness and quality of life in 96 patients with daytime sleepiness and snoring or mild to moderate obstructive sleep apnea.
This cohort study reports that intensive care units vary dramatically in how they manage care for patients admitted with treatment limitations.