This analysis of administrative health claims of nearly 19 million privately insured patients evaluates the association between chronic opioid use and surgery.
This systematic review and meta-analysis examines the efficacy, tolerability, and dose-dependent effects of opioid analgesics for low back pain.
This Viewpoint discusses the balance between the effective treatment of pain and preventing the abuse and misuse of opioids.
This study examines national patterns to identify effects on opioid analgesic prescribing before and after the US Drug Enforcement Administration’s rescheduling of hydrocodone combination analgesic products.
This Viewpoint discusses strategies for prevent overprescribing of opioids while still effectively treating patients in chronic pain.
This propensity score–adjusted cohort study finds that the risk of unintentional opioid overdose injury is related to the prescribed opioid’s duration of action. Accompanying editorial by Katz.
This retrospective cohort study determines that the increased risk of death associated with methadone use outside the hospital supports recommendations that it should not be a drug of first choice for treatment of noncancer pain.
This nested case-control analysis found that the initiation of tramadol therapy for noncancer pain is associated with an increased risk of hypoglycemia requiring hospitalization.
This randomized clinical trial reports that buprenorphine taper is less efficacious than ongoing maintenance treatment in patients dependent on prescription opioids in primary care.
Bachhuber et al determine the association between the presence of state medical cannabis laws and opioid analgesic overdose mortality in a time series analysis. See also the Invited Commentary by Hayes and Brown.
Baumblatt and coauthors assess the contribution of certain opioid-prescribing patterns to the risk of overdose death.