Meissner et al use studies of migraine prophylaxis to investigate whether different types of placebo treatments are associated with different responses. See also the Editor’s Note by Redberg.
This propensity score–adjusted cohort study finds that the risk of unintentional opioid overdose injury is related to the prescribed opioid’s duration of action. Accompanying editorial by Katz.
This multicenter, double-blind, sham-controlled clinical trial demonstrates that among service members with persistent postconcussion symptoms hyperbaric oxygen showed no benefits over sham compressions. See the Invited Commentary by Hoge and Jonas.
Miller and coauthors assess the risk of deliberate self-harm by antidepressant dose, by age group. See the Invited Commentary by Brent.