This study assesses the inclusion and prioritization of hypoglycemia in contemporary clinical guidelines and performance measures for patients with diabetes.
This pharmacoepidemiology study uses claims data to investigate the association between intensive glucose-lowering treatment and severe hypoglycemia among adults with type 2 diabetes between 2001 and 2013.
This case series describes HbA1c levels and frequency of hypoglycemia among older patients with type 2 diabetes whose treatment regimen was simplified to once-a-day glargine with or without noninsulin agents.
This randomized clinical trial compares the effects on HbA1c levels of adding liraglutide vs placebo to high-dose insulin treatment among patients with type 2 diabetes.
This survey study of primary care physicians assessed perceived barriers to deintensifying treatment in patients with diabetes at risk for hypoglycemia.
This cohort study evaluates the deintensification of medication used for glucose and blood pressure control in individuals older than 70 years with diabetes mellitus and discusses the possibility for reducing overtreatment.
Findings of this cross-sectional analysis suggest that a substantial proportion of older adults with diabetes were potentially overtreated.
This nested case-control analysis found that the initiation of tramadol therapy for noncancer pain is associated with an increased risk of hypoglycemia requiring hospitalization.
This retrospective cohort study found that diabetes treatment with metformin reduced subsequent treatment intensification, without differences in rates of adverse clinical events. See also the Invited Commentary by Segal and Maruthur.
Parekh and coauthors determined the risk of hypoglycemia and associated costs in older patients taking glipizide or glyburide who fill a prescription for an antimicrobial drug. Also see the Invited Commentary.
Lipska and coauthors characterize changes in hyperglycemia and hypoglycemia hospitalization rates and subsequent mortality and readmission rates among older adults in the United States over a 12-year period and compare these results according to age, sex, and race.
Geller et al describe the US burden, rates, and characteristics of emergency department visits and emergency hospitalizations for insulin-related hypoglycemia and errors. See also the invited commentary by Lee.
Tseng et al identify high-risk patients in the Veterans Health Administration with diabetes mellitus who had evidence of intensive glycemic management, and thus were at risk for serious hypoglycemia. See also the Editor’s Note by Steinbrook.
To evaluate the association between hypoglycemia and dementia, Yaffe et al studied 783 older adults with diabetes mellitus who were participating in the prospective population-based Health ABC Study beginning in 1997. Dementia diagnosis and hypoglycemic events were determined during the follow-up period. See the Invited Commentary by Lipska and Montori.