While direct oral anticoagulants (DOACs) hold some advantages over vitamin K antagonists, DOAC adverse effects, including bleeding, present a clinical challenge in frail older patients.
The authors discuss a case exemplifying the importance of clarifying a patient’s goals of care before conducting a surveillance computed tomographic scan of an asymptomatic tumor.
This randomized clinical trial found that 1 dose of zoledronic acid improved bone mineral density over 2 years in frail elderly women with osteoporosis, but the clinical importance of nonsignificant increases in fracture and mortality needs further study.
This longitudinal study raises questions regarding the safety of combination antihypertensive therapy regimen in frail elderly patients with low systolic blood pressure.
Findings of this cross-sectional analysis suggest that a substantial proportion of older adults with diabetes were potentially overtreated.