Among older persons with critical illness, this prospective cohort study finds that more than half died within 1 month or experienced significant functional decline over the following year. See the Editor’s Note by Covinsky.
Lamontagne and colleagues describe the frequency, anatomical location, risk factors, management, and consequences of nonleg deep venous thromboses in a large cohort of medical-surgical critically ill adults. Maynard provides an Invited Commentary.
MacLaren et al evaluate the occurrence and risk factors for gastrointestinal hemorrhage, pneumonia, and CDI in critically ill patients. Gross provides an Invited Commentary.
Using data from large clinical trials of previous years, Kox and Pickkers exemplify that less intensive treatment is associated with a better outcome in intensive care patients and suggest that we should reappraise both patient management as well as trial design in intensive care medicine while bearing in mind the “less is more” paradigm.