This cohort study reports on the association of receipt of antibiotics by prior hospital bed occupants with increased risk for Clostridium difficile infection in patients subsequently occupying the same bed.
This quasi-experimental controlled study investigates the effect of detecting and isolating Clostridium difficile asymptomatic carriers at hospital admission on the incidence of health care–associated C difficile infection in a Canadian acute care facility.
This cohort study of hospitalized adults with suspected Clostridium difficile infection compared complications and deaths among those with positive vs negative polymerase chain reaction and toxin immunoassay test results.
This case study serves as a reminder that the routine diagnostic tests for C difficile do not distinguish between active disease and colonization and that clinicians must consider, when appropriate, other potential causes of diarrhea, both infectious and noninfectious.
After adjustment for other independent predictors of recurrence, this retrospective cohort study finds that patients with continuous proton pump inhibitor exposure remained at elevated risk of Clostridium difficile infection recurrence.
This retrospective cohort study supports the use of antibiotic stewardship as a means of preventing Clostridium difficile infection.
Zimlichman and colleagues estimate costs associated with the most significant and targetable health care–associated infections. Katz comments in a related Editor’s Note.
To determine epidemiological and clinical characteristics of community-associated Clostridium difficile infection (CDI) and to explore potential sources of C difficile acquisition in the community, Chitnis et al performed an active population-based and laboratory-based CDI surveillance in 8 US states. See the Invited Commentary by Sepkowitz.