This cohort study evaluates the deintensification of medication used for glucose and blood pressure control in individuals older than 70 years with diabetes mellitus and discusses the possibility for reducing overtreatment.
This randomized clinical trial assesses whether discontinuing antihypertensive treatment improves cognitive, psychological, and general daily functioning in a population of elderly individuals with mild cognitive impairment and without serious cardiovascular disease.
This longitudinal study raises questions regarding the safety of combination antihypertensive therapy regimen in frail elderly patients with low systolic blood pressure.
This meta-analysis determines that vitamin D supplementation does not lower blood pressure in a population of patients using vitamin D or its analogues.
This cohort study finds that low daytime systolic blood pressure was independently associated with a greater progression of cognitive decline in older patients with dementia and mild cognitive impairment among those treated with antihypertensive drugs. See the Invited Commentary by Sabayan and Westendorp.
Landman and colleagues assess the efficacy of device-guided breathing on blood pressure in a meta-analysis of patient data from blinded, randomized, active-controlled trials.
Kovesdy et al compare the outcomes associated with a treated systolic blood pressure of less than 120 mm Hg vs those associated with the currently recommended systolic blood pressure of less than 140 mm Hg in a national chronic kidney disease database of US veterans.
Keyserling and colleagues assess the effectiveness, acceptability, and cost-effectiveness of a combined lifestyle and medication intervention to reduce coronary heart disease risk offered in counselor-based and web-based formats. In their related Invited Commentary, Moin and Mangione expand on the topic.
Hendriks et al report the effect of a community-based health insurance program on blood pressure in adults with hypertension in rural Nigeria.
Yokoyama et al conduct a systematic review and meta-analysis of controlled clinical trials and observational studies that have examined the association between vegetarian diets and blood pressure.
Williamson et al examine whether intensive therapy for hypertension and combination therapy with a statin and a fibrate reduce the risk of decline in cognition and total brain volume in patients with type 2 diabetes mellitus (T2DM). See the Invited Commentary by Dufouil and Brayne.
Witham and coauthors test whether vitamin D supplementation lowers blood pressure in older patients with isolated systolic hypertension. See Invited Commentary by Giovannucci.
Landman et al evaluate the effect of biofeedback with device-guided lowering of breathing frequency on blood pressure in patients with hypertension and type 2 diabetes mellitus, using a double-blind, sham-controlled design.